Institutional Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Roivant Sciences Ltd. 18,577,380 25.28 -- 7/31/21
Suvretta Capital Management, LLC 5,489,000 7.47 -- 9/30/21
Rubric Capital Management LP 3,000,000 4.08 -- 9/30/21
The Vanguard Group, Inc. 2,052,488 2.79 104,226 9/30/21
Hudson Bay Capital Management LP 1,605,000 2.18 65,000 9/30/21
Opaleye Management Inc. 955,000 1.30 -1,045,000 9/30/21
SV Inflections GmbH 841,371 1.14 841,371 6/30/21
Renaissance Technologies LLC 812,603 1.11 812,603 9/30/21
Medical Strategy GmbH 535,190 0.73 -- 9/30/21
Prosight Capital 493,208 0.67 237,093 9/30/21

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 1,382,708 1.88 97,664 12/31/21
SV Inflections Fund FCP-RAIF 841,371 1.14 841,371 6/30/21
Vanguard Extended Market Index Fund 593,038 0.81 -2,659 12/31/21
Bridgeway Ultra-Small Company Market Fund 398,300 0.54 100,000 9/30/21
MEDICAL BioHealth 313,897 0.43 -- 9/30/21
Fidelity Extended Market Index Fund 273,214 0.37 -704 11/30/21
APO Medical Opportunities 166,593 0.23 -- 3/31/21
DFA U.S. Small Cap Portfolio 158,475 0.22 158,475 10/31/21
iShares Micro-Cap ETF 130,378 0.18 728 12/31/21
Vanguard Balanced Index Fund 101,900 0.14 -- 12/31/21

* Insider values reflect direct beneficial ownership.

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